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. 2018 Nov 8;24(63):16783–16790. doi: 10.1002/chem.201803725

Scheme 1.

Scheme 1

a) Synthesis prodrugs 2 ad. (i) Alkyl halide, K2CO3, DMF, rt, overnight; or (ii) alkyl halide, K2CO3, MeCN, MW, 120 °C, 2 h. b) Proposed Pd‐triggered uncaging mechanism of 2 b,c.