A, Stern‐Volmer plot for the quenching of bimodal lipopolyplex F7‐(P1), surface targeted lipopolyplex F2‐(P4,P7), and surface targeted liposome F2(P4). The overall lipid concentration = 200 μM, peptide = 10 μM, luciferase plasmid DNA 0.02 μg/μL). The GE11 EGFR targeting sequence (YHWYGYTPQNVI) was present in all peptides, and the Trp emission at λem = 340 nm (λexc = 280 nm) was quenched upon addition of acrylamide (0‐50 mM). B, Stern‐Volmer plot for the quenching of F4‐BODIPY in surface targeted lipopolyplex F2‐(P4,P7) incorporating a final concentration of 2‐μM F4‐BODIPY bearing peptide P8, bimodal lipopolyplex F7‐(P1) incorporating a final concentration of 2‐μM F4‐BODIPY bearing peptide P9 (overall lipid concentration = 200 μM, peptide = 10 μM, F4‐BODIPY peptides = 2 μM, luciferase plasmid DNA 0.02 μg/μL). The BODIPY emission at λem = 530 nm (λexc = 557 nm) was quenched upon addition of acrylamide (0–50 mM)