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. 2018 Nov 29;9:2808. doi: 10.3389/fimmu.2018.02808

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Copyright © 2018 Camaioni, Klinger, Campagnolo and Salustri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of PTX3/HC/TSG6/HA interactions in cumulus matrix. During cumulus matrix formation, the binding of HA-linked HCs to the multimeric PTX3 molecule allows the crosslinking of several HA strands. TSG6, that catalyzes the transfer of HCs from CS of IαI to HA through the formation of an intermediate complex (TSG6-HC), also binds to PTX3. These interactions facilitate the simultaneous and coordinated integration of HCs and PTX3 within the cumulus matrix. (CS, chondroitin sulfate; LC, light chain; HC, heavy chain; HA, hyaluronan).