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. 2018 Oct 15;210(4):1369–1381. doi: 10.1534/genetics.118.301551

Figure 5.

Figure 5

PDF signaling acts upstream or in parallel to NCA channels. (A) Total time in sleep bouts for wild-type, pdfr-1(ok3425lf), pdf-1(tm1996lf), pdf-2(tm4393lf), and pdf-1tm1996(lf); pdf-2(tm4393lf) animals. (B) Response latency of wild-type, pdfr-1(ok3425lf), pdf-1(tm1996lf), pdf-2(tm4393lf), and pdf-1(tm1996lf); pdf-2(tm4393lf) animals to blue light stimulation during sleep bouts (left panel) and motion bouts (right panel). (C) Total time in sleep bouts for wild-type, pdfr-1(ok3425lf), nca-1(e625gf), and pdfr-1(ok3425lf); nca-1(e625gf) animals. (D) Model for genetic pathways of the conserved cation channel and gap junction proteins regulating sleep across species. Dashed arrows represent possible parallel pathway. All sleep bouts and motions bouts were assessed during L4 to adult lethargus. * P < 0.05, ** P < 0.01. All error bars represent standard error of the mean.