. 2018 Oct 19;210(4):1509–1525. doi: 10.1534/genetics.118.301311

Table 1. Toxins and PCs mapped per hotspot.

Toxin	Class	PCs in IVL	PCs in IVR	PCs in V
Cadmium	Heavy metal	0	0	0
Carmustine^a	Chemotherapeutic	1^a	0	1^a
Chlorothalonil^a	Pesticide	2^a	1^a	1^a
Chlorpyrifos	Pesticide	1	1	0
Cisplatin^a	Chemotherapeutic	2^a	1	2^a
Copper	Heavy metal	2	0	0
Diquat	Pesticide	0	0	0
Fluoxetine^a	Neuropharmaceutical	1	2^a	0
FUdR	Chemotherapeutic	1	1	0
Irinotecan^a	Chemotherapeutic	0	1^a	2
Mechlorethamine	Chemotherapeutic	0	0	1
Paraquat^a	Pesticide	0	0	1^a
Silver^a	Heavy metal	3^a	0	1^a
Topotecan	Chemotherapeutic	1	0	0
Tunicamycin	Chemotherapeutic	2^a	0	0
Vincristine	Chemotherapeutic	2	1	0

PC, principal component; IVL, hotspot on the center of chromosome IV; IVR, hotspot on the center of chromosome IV; V, hotspot on the center of chromosome V FUdR, Floxuridine.

Denotes a toxin tested with near-isogenic line and/or chromosome substitution strain assays.