Figure 2.

LOD score profile of the major identified QTL for blood glucose, body weight, and plasma insulin in the N₂ population of the NZOx129P2 and NZOxC3H cross. In the N₂(NZOx129P2) population, two QTL for blood glucose (Nbg4p and Nbg4d) were detected on chromosome 4 (A). Further QTL were detected in the N₂(NZOxC3H) population. A QTL for blood glucose and plasma insulin (Nbg4d) was detected at a similar position on chromosome 4 compared to Nbg4d from the N₂(NZOx129P2) population. Another locus on chromosome 4 (Nbw4) was associated with body weight (C). A QTL hotspot on proximal chromosome 7 (Nbg7p) revealed linkage with blood glucose, plasma insulin, and body weight. A second QTL for blood glucose was detected at a more distal position on chromosome 7 (Nbg7d) (B). Two further major QTL for blood glucose (Nbg15p and Nbg15d) were detected on chromosome 15 (D). Weeks of age are shown in brackets. The genotypic effects are indicated with the arrows. LOD scores were calculated using R/qtl software. Detailed information for each QTL is shown in Table 1. BG, blood glucose; BW, body weight; Chr., chromosome; ins, insulin; N/N, NZO/NZO; NZO, New Zealand Obese