Table 5.
Multivariate crude and adjusted OR for Decreasing-Low (n=70)a vs other THRT trajectory (n=1,101)
| Variables | Crude OR (95% CI) | Adjusted b OR (95% CI) | |
|---|---|---|---|
| Educational level-ongoing (years) | |||
| <9 | 4.31 (1.08–17.28) | 4.10 (1.05–16.03) | |
| 9–12 | 1 | 1 | |
| 12–16 | 0.74 (0.39–1.38) | 0.72 (0.38–1.35) | |
| >16 | 0.72 (0.36–1.41) | 0.70 (0.35–1.38) | |
| History of negative reproductive events | |||
| Yes | 0.66 (0.38–1.14) | 0.66 (0.38–1.14) | |
| No | 1 | 1 | |
Notes:
There was missing covariates information in 27.7% of the hypothyroid group (n=1,171): education (1.7%), smoking (20.3%), LTHMD (1.5%), BMI (2.6%), income (2.8%), pregnancy planning (0.9%), and negative reproductive history (1.5%).
Independent variables included in the main GEE model were educational level and history of negative reproductive events. These variables were selected using a combined, forward- and backward-model selection, based on the lowest AIC value.
Abbreviations: AIC, Akaike Information Criterion; BMI, body mass index; GEE, generalized estimating equation; LTHMD, lifetime history of major depression; THRT, thyroid hormone replacement therapy.