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. 2018 Nov 28;9:2784. doi: 10.3389/fimmu.2018.02784

Figure 3.

Figure 3

Benztropine induces a shift toward more CC1+ oligodendrocytes in EAE. The lumbar spinal cord region was isolated from control and treated mice at days 21 and 28 post-EAE induction. To visualize OPCs and mature OLs, immunostaining for NG2+ cells (green) and CC1+ cells (red) was performed. Cell nuclei were identified by DAPI (blue) (A). Numbers of NG2+ (B) and CC1+ (C) cells were counted per field and ratios of CC1+/NG2+ cells were calculated (D). Data are mean ± SEM. n = 3–4, *p < 0.05 compared to control. Scale bar: 20 um.