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. 2018 Nov 29;9:2792. doi: 10.3389/fimmu.2018.02792

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Copyright © 2018 Muxel, Acuña, Aoki, Zampieri and Floeter-Winter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram depicting unique and common miRNAs that were significantly differentially expressed in macrophages from WT or MyD88, TLR2 and TLR4 null mice infected with L. amazonensis. The miRNA expression levels in infected WT (purple), MyD88^−/− (yellow), TLR2^−/− (green), or TLR4^−/− (red) macrophages were examined. The upregulated (A) and downregulated (B) miRNAs in each group were compared to uninfected macrophages. The relative up- and downregulation of miRNAs are presented as boundaries of 1.2 or −1.2 of Fold Regulation, respectively. P-value < 0.05.