Fig. 2.

Disease-specific changes in lectin binding to HSMCs. Healthy (LHCN) immortalized human myoblasts (d0, open bars) and myotubes (d5, black bars) were compared to immortalized muscle cells from two patients with DMD (6311 and 6594). NPA, Jac and TJA-I binding to healthy myotubes increased on d5 compared to day 0, while binding of these lectins to dystrophic myotubes did not change or decreased. Increased binding of PHA-L, PNA, ACA, RCA-120, MAA-II, and WGA to d5 myotubes were observed regardless of disease-status. Human muscle cells did not bind DBA regardless of differentiation- or disease-status.