Images show functional connectivity (FC) mapping of nucleus basalis of
Meynert (NBM) cholinergic network (hereafter, NBM FC) (whole cohort) in,
A, healthy aging (healthy control participants
[HC], n = 33; corrected P ˂
.05) and also shows seed mask (green), B, in patients
with mild cognitive impairment (MCI) (n = 102;
corrected P ˂ .05), and, C, in
patients with Alzheimer disease (AD) (n = 33;
corrected P ˂ .05). Significance was set at
P ˂ .05. D, Difference NBM
FC map between MCI and HC (blue-light blue indicates reductions in MCI;
pairwise t test, corrected P ˂
.025). E, Difference NBM FC between late MCI (LMCI) and
early MCI (EMCI) (blue-light blue indicates reductions in LMCI; posthoc
pairwise t test, P ˂ .05).
F, Difference NBM FC between AD and HC (red-yellow
indicates increased FC in AD; pairwise t test,
corrected P ˂ .025). All results were masked by
gray matter masks obtained from Montreal Neurological Institute 152
standard-space T1-weighted average structural template image. All
t test analyses were controlled for age and mean
relative displacement.