Table 2.
Use category | No of person years | No of ovarian cancer events | Age standardised incidence per 100 000 person years | Adjusted relative risk (95% CI)* |
---|---|---|---|---|
Never use | 8 150 250 | 771 | 7.5 | 1.00 |
Ever use (any hormonal contraception) | 13 344 531 | 478 | 4.3 | 0.66 (0.58 to 0.76) |
Former use (any hormonal) | 4 505 157 | 244 | 5.0 | 0.77 (0.66 to 0.91) |
Current or recent use (any hormonal) | 8 839 374 | 234 | 4.0 | 0.58 (0.49 to 0.68) |
Current or recent use (combined oral) | 7 751 904 | 175 | 3.8 | 0.53 (0.45 to 0.64) |
Current or recent use (progestogen only) | 1 087 470 | 59 | 4.2 | 0.72 (0.55 to 0.95) |
Duration of current or recent use of any hormonal contraception† | ||||
≤1 year | 1 265 020 | 42 | 5.9 | 0.82 (0.59 to 1.12) |
>1-≤5 years | 4 063 111 | 103 | 4.6 | 0.62 (0.50 to 0.77) |
>5-≤10 years | 2 580 300 | 71 | 4.4 | 0.57 (0.44 to 0.74) |
>10 years | 930 943 | 18 | 1.7 | 0.26 (0.16 to 0.43) |
Time since last current use of any hormonal contraception‡ | ||||
>1-≤5 years | 2 442 620 | 110 | 5.0 | 0.76 (0.61 to 0.93) |
>5-≤10 years | 1 397 257 | 83 | 4.3 | 0.78 (0.61 to 0.99) |
>10 years | 665 281 | 51 | 3.8 | 0.80 (0.59 to 1.08) |
Adjusted for calendar year, parity, age, education, tubal sterilisation, hysterectomy, endometriosis, polycystic ovary syndrome, and family history of breast or ovarian cancer.
Ptrend<0.001.
Ptrend=0.03.