Table 3.
Frequency of use of specific selective serotonin reuptake inhibitors (SSRIs) during month before conception and in each month of first trimester of pregnancy. US National Birth Defects Prevention Study, births October 1997-August 2008. Figures are numbers (percentage)
| Type of SSRI | Mothers (n=57) of infants with congenital heart defects (n=1180) by month of pregnancy | Mothers (n=54) of control infants (n=1644) by month of pregnancy | Total (n=111) by month of pregnancy | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before | 1st | 2nd | 3rd | Total | Before | 1st | 2nd | 3rd | Total | Before | 1st | 2nd | 3rd | Total* | |||
| Sertraline | 15 (13.5) | 18 (16.2) | 14 (12.6) | 14 (12.6) | 23 (20.7) | 17 (15.3) | 16 (14.4) | 15 (13.5) | 14 (12.6) | 20 (18.0) | 32 (28.8) | 34 (30.6) | 29 (26.1) | 28 (25.2) | 43 (38.7) | ||
| Fluoxetine | 12 (10.8) | 10 (9.0) | 9 (8.1) | 7 (6.3) | 13 (11.7) | 14 (12.6) | 14 (12.6) | 11 (9.9) | 9 (8.1) | 17 (15.3) | 26 (23.4) | 24 (21.6) | 20 (18.0) | 16 (14.4) | 30 (27.0) | ||
| Paroxetine | 10 (9.0) | 8 (7.2) | 6 (5.4) | 6 (5.4) | 10 (9.0) | 13 (11.7) | 14 (12.6) | 13 (11.7) | 12 (10.8) | 14 (12.6) | 23 (20.7) | 22 (19.8) | 19 (17.1) | 18 (16.2) | 24 (21.6) | ||
| Citalopram | 10 (9.0) | 9 (8.1) | 2 (1.8) | 2 (1.8) | 10 (9.0) | 4 (3.6) | 4 (3.6) | 3 (2.7) | 3 (2.7) | 4 (3.6) | 14 (12.6) | 13 (11.7) | 5 (4.5) | 5 (4.5) | 14 (12.6) | ||
| Escitalopram | 5 (4.5) | 5 (4.5) | 4 (3.6) | 2 (1.8) | 5 (4.5) | 4 (3.6) | 5 (4.5) | 3 (2.7) | 3 (2.7) | 5 (4.5) | 9 (8.1) | 10 (9.0) | 7 (6.3) | 5 (4.5) | 10 (9.0) | ||
*Total does not equal 111 as some women used more than one type of SSRI.