Table 2.
Responsiveness of THAI #4 and 23 Mouse Lines to T3
| THAI #4 (T3) | ||||
|---|---|---|---|---|
| Tissue | Eu (RLU/mg Protein) | Hyper (RLU/mg Protein) | Fold (Means ± SEM) | P Value |
| Liver | 0.003 | 0.017 | 5.0 ± 0.6 | 0.009a |
| Heart | 0.006 | 0.284 | 45.9 ± 5.65 | 0.002a |
| #23 (T3) | ||||
|---|---|---|---|---|
| Tissue | Eu (RLU/mg Protein) | Hyper (RLU/mg Protein) | Fold (Means ± SEM) | P Value |
| MBH | 0.18 | 2.222 | 12.31 ± 2.4 | 0.003a |
Euthyroid animals were treated with L-T3 (IP 1 μg/g bw for 1 day). Luciferase activity was assessed in tissue samples with luciferase assay and expressed as RLU per milligram protein. Luciferase activity of corresponding tissues of TH vs vehicle-treated animals was performed by Student t test (n ≥ 4).
Abbreviation: MBH, mediobasal hypothalamus.
P < 0.05.