. 2017 Dec 14;159(2):1159–1171. doi: 10.1210/en.2017-00582

Table 3.

Responsiveness of Different Tissues and Brain Regions of THAI #4 to Hypothyroidism

Tissue	THAI #4 (Hypothyroid)
Tissue	Eu (RLU/mg Protein)	Hypo (RLU/mg Protein)	Fold (Means ± SEM)	P value
Pit	0.347	0.072	0.21 ± 0.02	0.0005^a
MBH	0.153	0.076	0.49 ± 0.04	0.0099^a
HT	0.315	0.136	0.43 ± 0.05	0.0032^a
CTX	0.163	0.056	0.34 ± 0.06	0.0003^a
Liver	0.003	0.001	0.44 ± 0.07	0.0446^a
Heart	0.009	0.001	0.16 ± 0.06	0.0001^a
BAT	0.037	0.008	0.23 ± 0.1	0.0051^a
Bone	0.031	0.008	0.26 ± 0.04	0.0034^a
Muscle	0.008	0.007	–	0.776
Thyroid	0.071	0.078	–	0.439
Intestine	1.683	0.166	0.1 ± 0.01	0.0001^a
WBC	0.013	0.005	0.42 ± 0.08	0.0412^a

Animals were rendered hypothyroid by adding 0.1% sodium perchlorate and 0.5% methimazole in drinking water for 3 weeks combined with a low-iodine diet. Luciferase activity was assessed with luciferase assay and expressed as RLU per milligram protein in tissue samples. Luciferase activity of corresponding tissues of hypothyroid vs euthyroid animals was compared with Student t test (n = 6).

Abbreviations: CTX, cerebral cortex; Eu, euthyroid; HT, hypothalamus; Hypo, hypothyroid; MBH, mediobasal hypothalamus; Pit, pituitary; WBC, white blood cell.

^{^a}

P < 0.05.