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. 2018 Jan 27;46(7):3671–3691. doi: 10.1093/nar/gky032

Figure 3.

Figure 3.

Sequence generalities of formation for different types of NCL events (see also Supplementary Table S5). (A) Distribution of TS-only events, circRNA-only events, TS-circRNA events and the events with dynamic NCL-splicing types across cell lines for the identified 24 899 NCL events. For simplicity, we integrated the last two groups of events for the analysis in (B–G). (B–D) Comparisons of distribution of genic position of exons (B), length of exonic NCL events (C), and length distribution of flanking introns at the donor (left) and acceptor sides (right) for the three types of NCL events (D). The control introns (10 000 introns, which do not overlap the flanking introns of the NCL events) were randomly selected from the NCL-host genes. The statistical significance in (D) was evaluated using the two-tailed Wilcoxon rank-sum test. ***P < 0.001. (E) Schematic illustration of a NCL event with five IRAluacross and four IRAluwithin pairs. (F) Comparisons of percentages of IRAluacross and (IRAluacross-IRAluwithin) ≥1 for the flanking introns of the three types of NCL events. (G) Comparisons of percentages of NCL junctions within SCEs for the three types of NCL events. The statistical significances in (F and G) were evaluated using the two-tailed Fisher’s exact test. *P < 0.05 and ***P < 0.001.