Table 2.

Comparison of Postoperative Laboratory Test Results Predicting Early Nonremission

Variable	AUROC	95% CI	Standard Deviation	n	P Value
POD-0 at noon cortisol	0.72	0.55, 0.90	0.852	89	0.013
POD-0 at 6 pm cortisol	0.85	0.77, 0.93	0.456	118	0.019
POD-0 avg cortisol	0.85	0.76, 0.94	0.509	125	0.034
POD-1 at midnight cortisol	0.91	0.85, 0.96	0.297	115	0.122
POD-1 at 6 am cortisol	0.96	0.93, 0.99	0.188	142	—
POD-0 at noon ACTH	0.76	0.60, 0.92	0.718	80	0.018
POD-0 at 6 pm ACTH	0.73	0.60, 0.86	0.713	116	0.001
POD-0 avg ACTH	0.73	0.59, 0.86	0.771	123	0.002
POD-1 at midnight ACTH	0.74	0.63, 0.85	0.617	117	0.000
POD-1 at 6 am ACTH	0.82	0.72, 0.93	0.618	136	0.018
NEPV cortisol	0.78	0.61, 0.95	0.768	78	0.047
NEPV ACTH	0.80	0.61, 0.98	0.784	71	0.093

Results of AUROC analyses with early nonremission as the reference variable. Nonremission was defined as no postoperative cortisol level <5 μg/dL within 10 days of surgery. P values from two-sample t tests after testing for variance equality, with POD-1 at 6 am cortisol chosen as the control. NEPVs for cortisol and ACTH were calculated as the difference between serum levels at POD-0 at noon and average preoperative post–CRH-stim test values.