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. 2017 Oct 10;159(1):323–340. doi: 10.1210/en.2017-00738

Figure 7.

Figure 7.

Loss of IGFIR/IR increased obesity susceptibility and induced a redistribution of the adipose organ. (a) Representative images from NMR comparing 3-month-old WT (n = 15) and DKO (n = 9) mice. (b) Quantification of NMR images. The results are presented as the percentage of fat volume per total volume. (c) Graph representing the epididymal WAT (eWAT), inguinal WAT (iWAT), retroperitoneal WAT (rWAT), and mesenteric WAT (mWAT) weights per total body weight comparing 3-month-old WT (n = 18) and DKO (n = 15) mice. (d) Hematoxylin and eosin–stained sections of different WAT depots from 3-month-old WT (n = 3) and DKO (n = 3) mice (magnification, ×20). White adipocyte size (square micrometers) from WAT depots is shown comparing 3-month-old WT (n = 3) and DKO (n = 3) mice (200 adipocytes per group) at magnification of ×20. Adipocyte number quantification from iBAT compartment comparing 3-month-old WT (n = 3) and DKO (n = 3) mice (six images per group). All results were presented as mean ± standard error of the mean. Statistical significance was assessed by two-tailed Student t test; *P < 0.05, **P < 0.01, and ***P < 0.001 between WT and DKO groups.