Table 2.

Gonadal Steroid Levels in Patients With Acromegaly Before and After Biochemical Control of Acromegaly and in Controls

Variable	Acromegaly Pretherapy (n = 20)	Acromegaly Posttherapy (n = 16)	Controls (n = 20)	P Value Acromegaly Pretherapy vs Controls	P Value Acromegaly Pretherapy vs Posttherapy	P Value Acromegaly Posttherapy vs Controls
Free testosterone, ng/dL, men	8.8 (5.4, 11.8)	10.9 (7.6, 15.1)	10.0 (8.6, 13.1)	0.2	0.2	0.9
Free testosterone, ng/dL, women	0.5 (0.4, 0.7)	0.4 (0.2, 0.5)	0.3 (0.1, 0.5)	0.1	0.2	0.9
Total testosterone, ng/dL, men	220 (143, 294)	321 (243, 429)	431 (274, 583)	0.01	0.07	0.2
Total testosterone, ng/dL, women	29 (17, 51)	18 (9, 30)	25 (15, 33)	0.5	0.8	0.4
Estradiol, pg/mL, men	17 (14, 20)	20 (16, 28)	29 (26, 42)	0.02	0.9	0.03
Estradiol, pg/mL, women	33 (7, 70)	8 (7, 36)	16 (6, 139)	0.9	0.8	0.6
SHBG, nmol/L, men	13 (10, 17)	17 (12, 25)	28 (18, 43)	0.003	0.1	0.07
SHBG, nmol/L, women	40 (25, 62)	34 (29, 61)	62 (42, 102)	0.1	0.5	0.06

Data are presented as mean ± standard deviation for normally distributed data and as median (interquartile range) for nonnormally distributed data. Data are presented as median (interquartile range). P values in boldface are significant.