Figure 2.

Chronic IN insulin application for 4 weeks reduces circulating BCAA levels. Fasting plasma BCAA levels at baseline and weeks 2 and 4 following IN insulin or placebo treatment. (a) Baseline-adjusted plasma BCAA levels. (b) Area under the curve (AUC) of the graphs depicted in panel (a). Pearson correlation of baseline Matsuda index and absolute change in BCAA levels after 4 weeks of IN insulin treatment (c). All error bars are SEM; P values vs the control group or as indicated by the bracket; n = 10 per group.