Figure 3.

IN insulin administration for 4 weeks does not change glucose tolerance. Plasma glucose levels at the indicated time points after an oral glucose load at baseline (a) and after 4 weeks of IN insulin or placebo (b). Plasma insulin levels at the indicated time points measured during the oral glucose tolerance test at baseline (c) and after 4 weeks of IN insulin or placebo (d). Corresponding areas under the curve (AUCs) of glucose (e) and insulin (f) levels depicted in panels (a–d) at baseline and after 4 weeks of IN insulin/placebo treatment. All error bars are SEM; P value vs the control group; n = 10 per group.