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. 2018 Dec 6;13(12):e0208824. doi: 10.1371/journal.pone.0208824

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© 2018 Morgan et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — Notes: The dates shown above the timeline are the PBS listing (reimbursement) dates while the dates shown below the timeline are the Therapeutic Goods Administration (TGA) registration (market approval) dates for each of the approved indications for NOAC use. Legend: Red: prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective total hip or total knee replacement surgery; Green: prevention of stroke and systemic embolism in (adult) patients with non-valvular atrial fibrillation (AF) and at least one additional risk factor for stroke; Blue: Treatment (Tx) of deep vein thrombosis (DVT) and pulmonary embolism (PE) and for the prevention (Pv) of recurrent DVT and PE in adults.