Fig 5. Electrostatic surface representation of substrate and product binding.

(A) Mevalonate-bound and (B) 5-phosphomevalonate-bound MmMK shown in surface, with electrostatic potentials calculated using the Adaptive Poisson-Boltzmann Solver [31] in PyMOL [32], in which blue depicts greater positive charge, red depicts greater negative charge, and white depicts neutral regions. Mevalonate and 5-phosphomevalonate are shown as sticks.