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. 2018 Dec 6;13(12):e0207843. doi: 10.1371/journal.pone.0207843

Table 1. Demographic and clinical characteristics of subjects according to hyperfiltration status after adjusting for age, sex, and body weight.

Parameter Hyperfiltration (-) Hyperfiltration (+)
N (%) 15109 (94.9) 809(5.1)
Age, years 50.08±16.07 46.67±16.43 <0.001
Male gender, (% 42.1 41.8 0.854
BMI, kg/m2 23.69±0.01 24.03±0.05 <0.001
Waist circumference, cm 80.78±0.04 82.26±0.16 <0.001
Current smoking, % 18.7 23.8 <0.001
Alcohol consumption, % 48.2 52.8 0.018
SBP, mmHg 118.2±0.1 119.9±0.5 0.001
DBP, mmHg 75.4±0.1 75.1±0.3 0.463
Antihypertensive medication, % 18.9 13.8 <0.001
HbA1c, % 5.772±0.006 5.843±0.025 0.006
Fasting plasma glucose, mg/dL 97.97±0.16 100.49±0.69 <0.001
Diabetes mellitus, % 9.7 10.5 0.401
Diabetes duration, years 8.30±7.52 7.19±7.26 0.240
Antidiabetic medication, % 6.17 7.05 0.314
Insulin therapy, % 0.51 0.49 0.952
Total cholesterol, mg/dL 189.6±0.3 188.5±1.2 0.391
Triglyceride, mg/dL 129.9±0.8 146.8±3.4 <0.001
HDL-cholesterol, mg/dL 52.72±0.10 53.17±0.41 0.291
Lipid lowering medication, % 7.3 3.3 <0.001
Serum creatinine, mg/dL 0.824±0.001 0.622±0.003 <0.001
eGFR, ml/min/1.73 m2 94.49±0.08 110.47±0.35 <0.001
Urine creatinine, g/dL 1.543±0.062 1.278±0.267 <0.001
Urine albumin, mg/dL 0.136±0.003 0.163±0.012 0.036
ACR, mg/g 0.951±0.018 1.399±0.079 <0.001
Energy intake, kcal 2019±7 2094±29 0.010
Water intake, g 1064±5 1089±23 0.293
Protein intake, g 71.67±0.32 73.43±1.38 0.215
Fat intake, g 42.18±0.26 42.81±1.12 0.580
Carbohydrate intake, g 319.5±1.0 326.3±4.5 0.215
Sodium intake, mg 4487±25 4579±110 0.421

BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; eGFR, estimated glomerular filtration rate; ACR, albumin creation ratio