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. 2018 Dec 6;13(12):e0208316. doi: 10.1371/journal.pone.0208316

Fig 8. Model of interaction between Prdx1 and Prdx2 in the detoxification of hydroperoxides of BTI RBCs.

Fig 8

An increase in ROS production during the development of RBCs results in Keap1 oxidation and consequent liberation of free Nrf2, contributing to the upregulation of Prdx1 and Sod1. In the bloodstream the upregulation of Prdx1 can act together with Sod1 and Prdx2 in the detoxification of ROS. In addition, Prdx1 associated with Trx1 leads to decrease in apoptosis. Altogether, these processes contribute to increase BTI RBCs lifespan.