. Author manuscript; available in PMC: 2018 Dec 6.

Published in final edited form as: Exp Clin Psychopharmacol. 2018 Jul 23;26(6):525–540. doi: 10.1037/pha0000216

Table 4:

Results of the inferential tests used to analyze the raw proportion of responses for the large magnitude reinforcer, AUCs, and omissions following administration of Ro 63–1908 and CP-101,606 in probability discounting.

Ro 63–1908					CP-101,606

Raw Proportion of Responses					Raw Proportion of Responses

Factor	DF	F Statistic	P	η_p²	Factor	DF	F Statistic	P	η_p²
Probability	1.985, 43.666	155.276	<.001	.876	Probability	1.533, 33.717	198.688	< .001	.900
Schedule	1,22	3.247	.085	.129	Schedule	1.22	16.037	.001	.422
Dose	2.273, 49.999	1.188	.317	.051	Dose	2.101. 46.233	0.132	.886	.006
Probability × Schedule	1.985, 43.666	4.401	.018	.167	Probability × Schedule	1.533, 33.717	12.104	< .001	.355
Probability × Dose	5.182, 114.010	0.668	.782	.029	Probability × Dose	5.160, 113.526	1.536	.182	.065
Schedule × Dose	2.273, 49.999	4.234	.016^a	.161	Schedule × Dose	2.101, 46.233	3.048	.055	.122
Probability × Dose × Schedule	5.182, 114.010	1.620	.158	.069	Probability × Dose × Schedule	5.160, 113.526	2.209	.056	.091

AUC					AUC

Factor	DF	F Statistic	P		Factor	DF	F Statistic	P

Schedule	1.22	10.157	.004		Schedule	1,22	24.946	< .001
Dose	3. 66	1.074	.366		Dose	3,66	0.093	.964
Schedule × Dose	3.66	4.249	.008^b		Schedule × Dose	3,66	3.156	0.031^c

Omissions					Omissions

Schedule	DF	χ²	n	P	Schedule	DF	χ²	n	P

Ascending	3	1.462	12	.691	Ascending	3	3.000	12	.392
Descending	3	6.000	12	.122	Descending	3	0.000	12	1.000

To probe the significant interaction, separate two-way ANOVAs were conducted for each schedule, with probability and dose as within-subjects factors. For rats tested in the ascending schedule, there was a main effect of probability only, F(1.454, 15.990) = 77.862, p < .001, η_p² = .876, although there was a trend for Ro 63-1908 to increase responses for the large, probabilistic reinforcer, F(3, 33) = 2.706, p = .061, η_p² = .197. For rats tested in the descending schedule, there was a main effect of probability only, F(1.717, 18.883) = 81.503, p < .001, η_p² = .881, although there was a trend Ro 63-1908 to decrease responses for the large, probabilistic reinforcer, F(3, 33) = 2.720, p = .060, η_p² = .198.

Contrasts showed that Ro 63-1908 (0.3 mg/kg) significantly increased AUCs when an ascending schedule was used (p = .004), whereas Ro 63-1908 (1.0 mg/kg) significantly decreased AUCs when a descending schedule was used.

Contrasts showed that CP-101,606 (1.0 mg/kg) significantly increased AUCs when an ascending schedule was used (p = .040), whereas CP-101,606 (3.0 mg/kg) significantly decreased AUCs when a descending schedule was used (p = .046).