Table 1:
Description of characteristics of the US and UK Myotonic Dystrophy Type 1 (DM1) study participants.
| US Cohort | UK Cohort | |
|---|---|---|
| Number of Participants with DM1 | 208 | 189 |
| Age at Interview;(years; Median (IQR))* |
53 (18.0) | 47 (19.5) |
| DM Inheritance: | ||
| Maternal | 47 (23%) | 35 (19%) |
| Paternal | 71 (34%) | 83 (44%) |
| Unknown | 90 (43%) | 71 (38%) |
| Age at Onset (years; Median (IQR))* |
25.5 (23.0) | 27.0 (20.5) |
| Age at Diagnosis (years; Median (IQR))* |
33.0 (23) | 33.0 (18) |
| Sex (% Female) | 115 (55%) | 98 (52%) |
| Personal History of Cancer (n/% Yes) |
62 (30%) | 11 (6%) |
| Personal History of benign Tumor(n/% Yes) |
34 (16%) | 17 (9%) |
| Number of Children: | ||
| 0 | 99 (48%) | 106 (56%) |
| 1 | 34 (16%) | 28 (15%) |
| 2 | 42 (20%) | 37 (20%) |
| ≥3 | 32 (15%) | 18 (10%) |
| Number of Siblings: | ||
| 0 | 18 (9%) | 41 (22%) |
| 1 | 62 (30%) | 73 (39%) |
| 2 | 58 (28%) | 52 (28%) |
| 3 | 35 (17%) | 9 (5%) |
| ≥4 | 35 (17%) | 7 (4%) |
*
IQR: inter-quartile range; defined as the difference between the 75th and 25th percentiles of the observed quantity.