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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: Neuron. 2018 Nov 1;100(5):1059–1065.e4. doi: 10.1016/j.neuron.2018.10.011

Figure 2. Blocking photoreceptor to bipolar cell signaling abolishes light-evoked wave initiation.

Figure 2.

a. Heatmaps representing ∆F/F of example RGC responses to light onset and offset in ACSF (left), L-AP4 (middle), and L-AP4+UBP 310 (right). Note ipRGC responses are preserved during light onset in presence of photoreceptor-bipolar cell antagonists (top right). Scale bar = 50 µm.

b. Light modulates the frequency of glutamatergic waves via activation of conventional photoreceptors. Top: Summary data depicting mean success rate of starting a wave on either the onset or offset of a light stimulus. n = 3 retinas per group. Bottom: Same as top but the order of the drugs was switched. n = 4 retinas per group. Error bars, SD. *p < 0.05 Dunn-Sidak.