Table 2.
Patient health in the USA by ATTR amyloidosis type
| Patients with ATTR-PN | Patients with ATTR-CM | Patients with both ATTR-PN and ATTR-CM | |
|---|---|---|---|
| SF-12 Health Survey scorea, n | 27 | 6 | 11 |
| Physical Health Summary | 34.4 (11.7) | 32.0 (9.5) | 23.4 (7.3) |
| Mental Health Summary | 45.8 (10.1) | 54.2 (8.6) | 47.2 (11.2) |
| HADS score, n | 27 | 6 | 11 |
| Depression subscale | 6.2 (3.2) | 6.0 (3.5) | 6.1 (2.0) |
| Anxiety subscale | 6.1 (4.1) | 4.2 (4.1) | 5.5 (3.3) |
| Pain, n | 27 | 6 | 11 |
| Pain, right now | 3.6 (3.2) | 0.8 (2.0) | 2.6 (1.4) |
| Average pain, past week | 3.6 (3.1) | 0.8 (1.6) | 3.0 (1.6) |
| Worst pain, past week | 4.7 (3.4) | 1.2 (1.8) | 5.0 (2.8) |
| EQ-5D-3L health survey, n | 27 | 6 | 11 |
| Mobility | 1.7 (0.5) | 1.7 (0.5) | 1.9 (0.3) |
| Self-care | 1.3 (0.5) | 1.0 (0.0) (NA) | 1.5 (0.7) |
| Usual activities | 2.0 (0.5) | 1.7 (0.8) | 2.3 (0.6) |
| Pain/discomfort | 1.8 (0.6) | 1.3 (0.5) | 1.8 (0.4) |
| Anxiety/depression | 1.5 (0.5) | 1.2 (0.4) | 1.3 (0.5) |
| Utility index score | 0.71 (0.2) | 0.83 (0.2) | 0.66 (0.2) |
| Overall health status rating | 59.6 (20.7) | 63.2 (12.7) | 46.2 (19.8) |
| Kansas City cardiomyopathy score, n | 6 | 11 | 17 |
| Physical limitation | 61.1 (26.1) | 31.1 (25.9) | 41.7 (29.2) |
| Symptom stability | 54.2 (10.2) | 45.5 (10.1) | 48.5 (10.7) |
| Symptom frequency | 65.6 (21.9) | 37.9 (21.6) | 47.7 (25.1) |
| Symptom burden | 68.1 (23.8) | 41.7 (20.1) | 51.0 (24.5) |
| Total symptom | 66.8 (22.5) | 39.8 (19.3) | 49.3 (23.8) |
| Self-efficacy | 81.3 (20.5) | 77.3 (22.2) | 78.7 (21.1) |
| Quality of life | 57.0 (23.8) | 46.2 (15.1) | 50.0 (18.6) |
| Social limitation | 44.8 (27.8) | 24.6 (21.4) | 31.8 (25.0) |
| Overall summary | 57.4 (18.9) | 35.4 (16.5) | 43.2 (20.0) |
| Clinical summary | 64.0 (23.8) | 35.4 (20.3) | 45.5 (25.2) |
All assessment scores are mean (standard deviation) unless otherwise indicated
EQ-5D-3L EuroQol–5 Dimensions–3 Levels questionnaire, HADS Hospital Anxiety and Depression Scale, NA not available, SF-12 12-Item Short Form Health Survey (version 2)
aThe 1-week recall version of the SF-12 form was used in Spain and the 4-week recall version was used in the USA