Tab.2.
Factors, levels and scoring standard of orthogonal design
| EE(100%) | score | DL (%) | score | Diameter (nm) | score | Zeta potential (mV) | score |
|---|---|---|---|---|---|---|---|
| EE(100%) | score | DL (%) | score | Diameter (nm) | score | Zeta potential (mV) | score |
| 40 | 1 | 2 | 1 | 250 | 10 | 10 | 1 |
| 40,45 | 2 | [2,3) | 2 | 250,275 | 9 | 10,11.875 | 2 |
| 45,50 | 3 | [3,4) | 3 | 275,300 | 8 | 11.875,13.75 | 3 |
| 50,55 | 4 | [4,5) | 4 | 300,325 | 7 | 13.75,15.625 | 4 |
| 55,60 | 5 | [5,6) | 5 | 325,350 | 6 | 15.625,17.5 | 5 |
| 60,65 | 6 | [6,7) | 6 | 350,375 | 5 | 17.5,19.375 | 6 |
| 65,70 | 7 | [7,8) | 7 | 375,400 | 4 | 19.375,21.25 | 7 |
| 70,75 | 8 | [8,9) | 8 | 400,425 | 3 | 21.25,23.125 | 8 |
| 75,80 | 9 | [9,10) | 9 | 425,450 | 2 | 23.125,25 | 9 |
| ≥80 | 10 | ≥10 | 10 | ≥450 | 1 | ≥25 | 10 |
EE: entrapment efficiency; DL: drug loading.