Tab.4.
Statistical analysis of orthogonal design for sum, EE, DL, particle size, and zeta potential of MTZ-CS-SLNs
| SLN characterization | Statistical parameter | MTZ | Phospholipids | GMS | Coemulsifiers | Chitosan |
|---|---|---|---|---|---|---|
| Sum | K1 | 3.850 | 4.950 | 5.125 | 3.275 | 3.175 |
| K2 | 3.875 | 3.800 | 4.625 | 3.725 | 4.075 | |
| K3 | 3.575 | 2.750 | 2.725 | 4.025 | 4.825 | |
| K4 | 3.975 | 3.775 | 2.800 | 4.250 | 3.200 | |
| Rj | 0.400 | 2.200a | 2.400a | 0.975 | 1.650a | |
| EE | K1 | 51.375 | 39.650 | 58.350 | 43.050 | 45.950 |
| K2 | 55.400 | 49.075 | 60.075 | 52.200 | 57.150 | |
| K3 | 53.275 | 58.900 | 48.075 | 60.000 | 49.625 | |
| K4 | 49.025 | 61.450 | 42.575 | 53.825 | 56.350 | |
| Rj | 6.375 | 21.800a | 17.500a | 16.950 | 11.200 | |
| DL | K1 | 1.280 | 3.860 | 6.218 | 3.123 | 3.010 |
| K2 | 3.920 | 3.343 | 5.090 | 4.025 | 4.793 | |
| K3 | 4.695 | 4.617 | 3.025 | 5.185 | 3.662 | |
| K4 | 6.585 | 4.660 | 2.147 | 4.147 | 5.015 | |
| Rj | 5.305a | 1.317 | 4.071 | 2.062 | 2.005 | |
| Diameter | K1 | 403.125 | 337.675 | 357.325 | 398.350 | 365.150 |
| K2 | 419.850 | 368.675 | 355.075 | 439.525 | 367.525 | |
| K3 | 380.975 | 469.650 | 400.175 | 380.275 | 366.900 | |
| K4 | 382.475 | 410.425 | 473.850 | 368.275 | 486.850 | |
| Rj | 38.875 | 131.975a | 118.775 | 71.250 | 121.700a | |
| Zeta potential | K1 | 14.675 | 18.125 | 14.475 | 12.625 | 11.175 |
| K2 | 13.350 | 13.450 | 13.400 | 13.975 | 10.675 | |
| K3 | 10.375 | 8.425 | 10.800 | 13.075 | 17.800 | |
| K4 | 13.375 | 11.775 | 13.100 | 12.100 | 12.125 | |
| Rj | 4.300 | 9.700a | 3.675 | 1.875 | 7.125a |
aP 0.05. MTZ: methazolamide; GMS: glyceryl monostearate; EE: entrapment efficiency; DL: drug loading.