Tab.6.
Statistical analysis for Box-Behnken design of EE, diameter, and zeta potential
| Parameters | EE | Diameter | Zeta potential | |||
|---|---|---|---|---|---|---|
| Coefficient | P-value | Coefficient | P-value | Coefficient | P-value | |
| Intercept | 54.16 | 0.0001 | 358.38 | 0.0015 | 16.44 | 0.0001 |
| A-GMS | 3.42 | 0.0001 | 7.610 | 0.4179 | -3.65 | 0.0004 |
| B-phospholipids | 9.87 | 0.0001 | 80.35 | 0.0001 | -12.53 | 0.0001 |
| C-chitosan | 0.17 | 0.7092 | -1.74 | 0.8498 | 8.06 | 0.0001 |
| AB | -4.21 | 0.0003 | -1.65 | 0.8988 | 0.85 | 0.3276 |
| AC | 0.69 | 0.3115 | -23.43 | 0.1032 | -3.20 | 0.0054 |
| BC | -0.30 | 0.6528 | 5.45 | 0.6762 | -0.62 | 0.4648 |
| A^2 | -3.47 | 0.0008 | -3.05 | 0.8095 | 2.03 | 0.0364 |
| B^2 | -1.68 | 0.0290 | -50.58 | 0.0043 | 6.13 | 0.0001 |
| C^2 | 2.11 | 0.0106 | 37.55 | 0.0178 | 2.63 | 0.0123 |
| R-squared | 0.9893 | 0.9414 | 0.9916 |
aP 0.05. MTZ: methazolamide; GMS: glyceryl monostearate; EE: entrapment efficiency; DL: drug loading.