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. 2018 Dec 6;9:5211. doi: 10.1038/s41467-018-07566-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Excitability and neurotransmitter productions of dbh-disrupted LC neurons. a, b Firing rate (a) and the current clamp recordings (b) of the LC cells. The horizontal brain slices containing LC were prepared from the mice bilaterally injected with AAV-DJ sgControl or AAV-DJ sgDbh. The recordings were performed with 7 cells/3 animals (sgControl) and 8 cells/3 animals (sgDbh), respectively. c Quantification of norepinephrine in brain homogenates. The olfactory bulb (OB; left panel) or prefrontal cortex (PFC; right panel) were removed from the mice bilaterally injected with AAV-DJ sgControl (n = 6) or AAV-DJ sgDbh (n = 7). (*P < 0.05, **P < 0.01 by two-tailed Student t-test between sgControl and sgDbh; t = 3.516 (OB) and 2.382 (PFC), df = 11 (OB) and 11 (PFC)). d Quantification of norepinephrine (left panel) and dopamine (right panel) in the LC. The LC was removed from the mice unilaterally injected with DJ sgControl (n = 4–5) or AAV-DJ sgDbh (n = 5). (**P < 0.01 by two-tailed Student t-test between sgControl and sgDbh; t = 4.512 (norepinephrine) and 1.601 (dopamine), df = 8 (norepinephrine) and 7 (dopamine))