Fig. 2.
Interaction between AMN and cubilin. a AMN interface of the trimeric cubilin β-helix. The hydrophobic centre of the β-helix is formed by Met44 residues. b Cubilin interface of AMN. AMN in b is related to cubilin in a by a vertical rotation of 180°. c–e Interactions between the three individual polypeptide chains of cubilin with AMN. Residues directly involved in interactions are shown as sticks. Hydrogen bonds and ionic interactions are marked by dashed black lines