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. 2018 Dec 6;9:5218. doi: 10.1038/s41467-018-07731-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — TF binding and zygotic genome activation. a Sketch of zygotic mRNA levels as a function of embryo stage. Inset: schemes of embryos at different developmental stages. b Scheme of TF binding to chromatin: free TFs associate with rate constant k_on to and dissociate with rate constant k_off from an apparent number of chromatin binding sites D₀. The concentrations of all species involved depend on their quantities and the nuclear volume V_n. Inset: formula describing the chromatin-bound fraction of TFs that does not depend on the concentration of TFs