Fig. 7.

Multistudy factor analysis of autoantibodies. The multistudy factor analysis (MSFA) was performed to analyze autoantibodies (aab) from healthy donors (HD) compared with patients with a systemic sclerosis (SSc), b ovarian cancer (OC), and c Alzheimer’s disease (AD). Supplementary Tables 1 and 2 provide further details about the HD and patient groups, as well as the aab datasets analyzed. The images are heatmaps of estimated factor loadings of common and specific latent factors. The color scale bar ranging from orange (−1 to 1) to blue corresponds to negative and positive factor loadings. Loadings close to −1 or 1 indicate aab that strongly influence factors in opposite directions