Table 5.
Major functions of genes deregulated by a factor of two between male and female lactotroph tumors.
| Symbol | Expr fold change | Expr p-value | Description | Chromosome | Angiogenesis | Cell growth and proliferation | Cell death and survival | Cell morphology | Cellular movement | Development | Endocrine system | Estrogen signaling | Pituitary tumors | Sexual dimorphism | Symbol |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BHLHE41 | 2.077 | 0.00365 | Basic helix-loop-helix family member e41 | 12 | x | x | x | BHLHE41 | |||||||
| CDK8 | 2.599 | 5.59 10−5 | Cyclin dependent kinase 8 | 13 | x | x | CDK8 | ||||||||
| CHL1 | 3.117 | 0.0296 | Cell adhesion molecule L1 like | 3 | x | x | x | x | x | CHL1 | |||||
| CTAG2 | 2.332 | 0.0242 | Cancer/testis antigen 2 | X | x | x | CTAG2 | ||||||||
| ENC1 | 2.023 | 0.0336 | Ectodermal-neural cortex 1 | 5 | x | x | x | x | ENC1 | ||||||
| ERBIN | 2.008 | 0.0191 | Erbb2 interacting protein | 5 | x | x | x | x | x | ERBIN | |||||
| ETS2 | 2.366 | 5.76 10−4 | ETS proto-oncogene 2, transcription factor | 21 | x | x | x | x | ETS2 | ||||||
| EXT1 | 2.181 | 0.00196 | Exostosin glycosyltransferase 1 | 8 | x | x | x | x | EXT1 | ||||||
| EZR | −2.199 | 0.0187 | Ezrin | 6 | x | x | x | x | x | EZR | |||||
| FGF13 | 3.419 | 0.0067 | Fibroblast growth factor 13 | X | x | x | x | x | x | x | FGF13 | ||||
| FOXA1 | 2.35 | 0.0338 | Forkhead box A1 | 14 | x | x | x | x | x | x | x | FOXA1 | |||
| FOXQ1 | 5.758 | 0.0393 | Forkhead box Q1 | 6 | x | x | x | FOXQ1 | |||||||
| GADD45G | −2.656 | 0.0281 | Growth arrest and DNA damage inducible gamma | 9 | x | x | GADD45G | ||||||||
| ISL1 | 2.163 | 0.0338 | ISL LIM homeobox 1 | 5 | x | x | x | x | x | x | ISL1 | ||||
| KDM5D | 18.032 | 4.12 10−10 | Lysine demethylase 5d | Y | x | x | KDM5D | ||||||||
| LTBP1 | 2.246 | 0.0367 | Latent transforming growth factor beta binding protein 1 | 2 | x | x | x | x | x | x | x | LTBP1 | |||
| MYH7 | −4.706 | 0.00688 | Myosin heavy chain 7 | 14 | x | x | MYH7 | ||||||||
| NMU | 3.336 | 0.00721 | Neuromedin u | 4 | x | x | NMU | ||||||||
| OBSCN | 2.596 | 0.0158 | Obscurin, cytoskeletal calmodulin and titin-interacting rhogef | 1 | x | x | OBSCN | ||||||||
| PITX1 | 2.459 | 0.00579 | Paired like homeodomain 1 | 5 | x | x | x | x | PITX1 | ||||||
| PPID | 2.261 | 0.0369 | Peptidylprolyl isomerase d | 4 | x | x | PPID | ||||||||
| PTGS1 | 2.554 | 0.0263 | Prostaglandin-endoperoxide synthase 1 | 9 | x | x | x | x | PTGS1 | ||||||
| PTPRZ1 | 2.393 | 0.0496 | Protein tyrosine phosphatase, receptor type z1 | 7 | x | x | x | x | x | x | PTPRZ1 | ||||
| ROBO1 | 2.033 | 0.0144 | Roundabout guidance receptor 1 | 3 | x | x | x | x | x | x | ROBO1 | ||||
| SLC12A4 | 3.348 | 0.00534 | Solute carrier family 12 member 4 | 16 | x | x | SLC12A4 | ||||||||
| SLC2A11 | 2.342 | 0.0131 | Solute carrier family 2 member 11 | 22 | x | x | x | SLC2A11 | |||||||
| SLC6A8 | 2.577 | 0.00231 | Solute carrier family 6 member 8 | X | x | x | x | SLC6A8 | |||||||
| SNCB | 2.022 | 0.013 | Synuclein beta | 5 | x | x | x | SNCB | |||||||
| SOSTDC1 | 6.814 | 0.0103 | Sclerostin domain containing 1 | 7 | x | x | SOSTDC1 | ||||||||
| STAP2 | 2.122 | 0.00363 | Signal transducing adaptor family member 2 | 19 | x | x | STAP2 | ||||||||
| TSPAN8 | 3.232 | 0.0371 | Tetraspanin 8 | 12 | x | x | TSPAN8 | ||||||||
| VEGFD | 2.27 | 0.0363 | vascular endothelial growth factor d | X | x | x | x | x | x | x | VEGFD |