Table 1.
Frequently used TRM markers in mice and humans.
| Marker | Expression | Proposed function | Mouse | Human |
|---|---|---|---|---|
| CD69 | Almost all | Antagonisation of S1P1-mediated tissue egress | (4) | (17–19) |
| CD103 | Subset * | Epithelial location via binding to E-Cadherin | (4) | (18) |
| CD44 | All | Binding to hyaluronic acid | (20) | |
| Bcl-2 | Subset | Longevity | (21, 22) | (23) |
| CD49a | Subset | Binding to Collagen and Laminin, specialization of effector function | (4, 22) | (19, 24) |
| CD101 | Subset | Inhibition of T cell activation and proliferation | (25) | (19) |
| GrB | All | Cytotoxicity | (21, 26) | (24) |
| CD127 | Subset | Homeostatic proliferation | (27–29) | (30) |
| S1P1low | All | Low sensitivity to tissue egress signals | (31) | (19) |
| S1P5low | All | Low sensitivity to tissue egress signals | (22, 26) | |
| CD62L low | All | Low sensitivity to tissue egress signals | (21, 4) | (19) |
| Ccr7low | All | Low sensitivity to tissue egress signals | (26) | (18) |
| CX3CR1low | Subset | Low sensitivity to tissue egress signals | (26) | (19) |
| KLRG1low | All | High memory potential | (22, 29) |
*
Mucosal sites and skin. GrB, Granzyme B.