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. 2018 Jul 23;37(49):6285–6298. doi: 10.1038/s41388-018-0401-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Enhanced CXCR4 cell-surface expression and migratory ability in N3-ICtg thymocytes. a surface CXCR4 mean fluorescence intensity (MFI) on DP-gated thymocytes of WT (n = 4) and N3-ICtg (n = 5) mice; b CXCR4 mRNA expression in DP thymocytes of WT (n = 3) and N3-ICtg (n = 3) mice; c SDF-1 mRNA expression in whole thymi of WT (n = 3) and N3-ICtg (n = 3) mice; d Migration of WT (n = 3) and N3-ICtg (n = 3) DP thymocytes in response to (20–200 ng/ml) SDF-1, evaluated as fold increase of DP migrating thymocytes percentages in SDF-1 stimulated versus unstimulated thymocytes (CTRL). Unrelated ligand, SLC. Each experiment was performed with 6–8-week-old mice. Results represent mean ± SD. (*p < 0.05; **p<0.01; ***p < 0.001; ns, not significant; Student’s t-test)