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. 2018 Jul 23;37(49):6285–6298. doi: 10.1038/s41388-018-0401-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — High Notch3⁺CXCR4⁺ cell-surface co-expression characterizes N3-ICtg DP thymocytes. a Left: thymocytes subset distribution with average DP percentage ± SD. Right: DP-gated thymocytes with average percentage ± SD of Notch3⁺CXCR4⁺DP cells. WT (n = 3) and N3-ICtg (n = 4) mice. b Left: thymocytes subset distribution with average DP percentage ± SD; right: DP-gated thymocytes with average percentage ± SD of Notch3⁺CXCR4⁺DP cells. WT (n = 7) and N3-ICtg (n = 9) mice. c Absolute numbers of Notch3⁺CXCR4⁺ and/or Notch3^-CXCR4⁺DP normalized to total DP thymocytes values. Student’s t-test between WT and N3-ICtg at each age; symbols § and * indicate Notch3⁻CXCR4⁺ and Notch3⁺CXCR4⁺, respectively. For each corresponding age, WT (n = 4) and N3-ICtg (n = 5) mice were used. One-way ANOVA and Tukey’s post-test (left side) among different aged N3-ICtg (ns, not significant, **p < 0.01; ***p<0.001; ****p < 0.0001; ^§§§§p < 0.0001; ^§§p < 0.01). d CD4⁺CD8⁺Notch3^+highCXCR4^+high absolute numbers in N3-ICtg (n = 3) versus WT (n = 3) mice (*p < 0.05; **p < 0.01). See also Figure S1