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. 2018 Dec 6;9:5206. doi: 10.1038/s41467-018-07548-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Distinct LPS responses of engrafted macrophages and host microglia. a PC analysis of RNA seq data of graft and host microglia in steady state and 12 h post LPS. b Expression analysis of grafted cells and host microglia in steady state and 12 h post LPS by RNA seq. c Examples of genes expression of graft and host microglia in steady state and 12 h post LPS. Significance is indicated by the symbols (p-value < 0.05), or lack thereof (p-value>0.05). See Ccl6 plot (top right) for symbol to condition conversion. d Fold expression change of selected genes significantly different (absolute value of log2FC > 1, p-value < 0.05) following challenge in grafted cells (middle) or host microglia (right), as well as genes displaying comparable up- and downregulation in both engrafted cells and host microglia (left). Source data are provided as a Source Data file