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. 2018 Nov 30;9:1419. doi: 10.3389/fphar.2018.01419

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Copyright © 2018 Liu, Wu, Wang, Xie, Cui, He, He, Li, Liu, Hu, Cen and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The biological evaluation of candidate compounds. (A) MTT assay of candidate compounds in the LNCaP cells. (B) MTT assay of candidate compounds in the PC-3 cells. (C) The dual-luciferase assay of AR activity for candidate compounds in LNCaP cell. (D) The dual-luciferase assay of AR activity for candidate compounds in LNCaP cell. Experiments were in triplicate. All results are shown as mean ± s.d. ^∗P < 0.05, ^∗∗P < 0.01 vs. DMSO group (MTT assay) or DHT group (dual-luciferase assay). ENZ, enzalutamide; DHT, dihydrotestosterone.