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. 2018 Nov 30;9:1400. doi: 10.3389/fphar.2018.01400

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Copyright © 2018 Ohsawa, Maruoka, Inami, Iwaki, Murakami and Ishikura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of NYT on the phosphorylation of STAT3 (A), SOCS3 expression (B), phosphorylation of Akt (C), and phosphorylation of GSK-3β (D) in the skeletal muscle of mouse with cancer cachexia. NYT was administered once a daily from 1 h before B16BF6 melanoma implantation and continued for 14 days. Samples were collected 24 h after last treatments. Each immunostaining obtained from same membrane. Each column represents the mean with SEM from three independent experiments. ^∗P < 0.05 vs. water-treated no-cancer group.