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. 2018 Nov 30;9:1400. doi: 10.3389/fphar.2018.01400

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Copyright © 2018 Ohsawa, Maruoka, Inami, Iwaki, Murakami and Ishikura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of NYT on the phosphorylation of 4E-BP1 (A), phosphorylation of AMP kinase (B), and the expression of myosin heavy chain (MHC) (C) in the skeletal muscle of mouse with cancer cachexia. NYT was administered once a daily from 1 h before B16BF6 melanoma implantation and continued for 14 days. Samples were collected 24 h after last treatments. Each immunostaining obtained from same membrane. Each column represents the mean with SEM from six independent experiments. ^∗P < 0.05 vs. water-treated no-cancer group. ^#P < 0.05 vs. water-treated cancer group.