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. 2018 Nov 30;9:2983. doi: 10.3389/fmicb.2018.02983

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Copyright © 2018 Panteleev, Bolosov, Kalashnikov, Kokryakov, Shamova, Emelianova, Balandin and Ovchinnikova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Minimum inhibitory concentrations (MIC) changes in bacterial strains E. coli XDR CI 1057 (A) and E. coli ML-35p (B) exposed to selection by individual goat cathelicidins ChMAP-28 (MIC value at transfer “1” = 0.125 μM) or mini-ChBac7.5Nα (MIC value at transfer “1” = 8 μM), the synergistic combination of ChMAP-28 + mini-ChBac7.5Nα (MIC value at transfer “1” = 0.03 + 2 μM, respectively), and the reference antibiotic polymyxin B (MIC value at transfer “1” = 0.125 μM). The experiment was performed in the Mueller-Hinton broth supplemented with 0.9% NaCl at 37°C. 26 repeated passages (transfer N) in the presence of antimicrobial agents were made for each bacterial strain during the experiment.