Table 4.
Antibacterial activity of goat cathelicidins and polymyxin B against E. coli strains obtained after selection experiment.
| Strain | Minimum inhibitory concentration (μM) |
||
|---|---|---|---|
| Polymyxin B | ChMAP-28 | mini-ChBac7.5Nα | |
| E. coli XDR CI 1057 (0 days) | 0.125 | 0.125 | 8 |
| E. coli XDR CI 1057 (26 days without antimicrobial agent) | 0.125 | 0.125 | 8 |
| E. coli XDR CI 1057 (26 days with polymyxin B) | >128 | 0.25 | 64 |
| E. coli XDR CI 1057 (26 days with mini-ChBac7.5Nα) | 0.125 | 0.125 | >128 |
| E. coli XDR CI 1057 (26 days with synergy combination) | 0.06 | 0.125 | 8 |