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. 2018 Dec;95:1–14. doi: 10.1016/j.jaut.2018.10.017

Fig. 6.

Fig. 6

Evaluation of pharmacodynamic biomarkers in cynomolgus. In vivo dose and time-dependent changes in IgG-(IL-2N88D)2-induced (A) pSTAT5, (B) CD25 and (C) % of cells Ki-67+; ■ = 100 μg/kg, ▲ = 30 μg/kg. (D) Maximal dose-dependent changes in FOXP3 at 30 and 100 μg/kg. (E) Time-dependent changes in CD4+ Tregs compared to total CD4+ memory effector T cells; 100 μg/kg dose. Results in A-E are shown as the mean ± SD, n = 4. (F) Time-dependent changes in CD4+CD25+ memory effector T cells; individual animals (n = 4). (G) Effects IgG-(IL-2N88D)2 (100 μg/kg), wild type IgG-IL-2 (36 μg/kg) and Proleukin (see dosing regimen detailed in Fig. 4A) and the effects on eosinophils and Tregs; each symbol represents an individual animal. Proleukin results were published previously (29) and are shown for comparison.