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. 2018 Nov 30;9:2932. doi: 10.3389/fmicb.2018.02932

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Copyright © 2018 Bruhn, Schindler, Kemter, Wiley, Chase, Koroleva, Palacios, Sozhamannan and Waldminghaus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Marker frequency analysis of engineered single chromosome V. cholerae strains VC61 (A) and VC62 (B). Left panel: Genomic maps of VC61 (analogous to NSCV1) and VC62 (analogous to NSCV2) showing the respective locations of ori1, ori2, and crtS. Right panel: Profiles of genome-wide copy numbers based on Illumina sequencing. Gray dots represent log numbers of normalized reads as mean values for 1 kbp windows relative to the stationary phase sample. Vertical dotted black lines mark the locations of replication origins of replication and the crtS sites. The solid black lines represent the fitting of regression lines and the green line corresponds to the Loess regression (F = 0.05). Maxima are highlighted by red and minima as blue dots. Plots of biological replicates are shown in Supplementary Figure S1.