Table 1.

Overview of published papers “Osteoarthritis pain animal models/mouse models” PubMed search Jan 6, 2018.

	% Before 2008 (total=36)	% Since 2008 (total=214)
MIA model	41%	54%
Surgical model	28%	33%
Collagenase-induced OA	N/A	3%
Other OA-relevant models (ageing, obesity)	3%	3%
Inflammatory models*	16%	6%
Large animals	19%	7%
Two models side-by-side	5%	8%
Includes neurobiology	25%	35%
Assesses more than one behavior	16%	32%
Pain assessed at more than one time point	25%	40%
Assesses pain and joint damage in same animals	33%	43%
DMOAD testing with pain as secondary outcome	5%	11%

^*These include intra-articular administration of CFA or carrageenan in order to trigger joint damage and pain. MIA = mono-iodoacetate; DMOAD = disease-modifying osteoarthritis drug.