Fig. 1.

Transient increase in CSF GAP-43 concentration after stroke. a GAP-43 concentration relative to each individual’s baseline and a piecewise-linear regression model displaying overall longitudinal trends between the five time points; b Baseline GAP-43 levels in controls (left of dotted line) and continuous individual longitudinal trajectories of absolute GAP-43 concentration after stroke, where each line represents a single individual (right of dotted line), showed a transient increase directly after stroke which returned to control levels for most individuals; c Relationship between the increase in GAP-43 concentration before 9 days and the subsequent decrease in GAP-43 concentration after 9 days; d GAP-43 concentration (median and interquartile range) in controls (left of dotted line) and in stroke patients at Day 0–1, Day 2–3, Day 7–9, 3 weeks and 3–5 months